吡非尼酮
中文同义词:哌非尼酮;5-甲基-1-苯基-2-(1H)-吡啶酮;吡非尼酮;吡非尼酮,哌非尼酮
英文名称:Pirfenidone
CAS号: 53179-13-8
分子式: C12H11NO

分子量: 185.22

规格：≥99%

检测指标：

产品类别：医药中间体

用途：主要用于新型抗纤维化原料,具有广谱的抗肺、肝、肾、心和腹膜纤维化作用。

Application:

In vitro, pirfenidone can inhibit the uterine flesh tumour cellsand leiomyoma cells proliferation. Pirfenidone can inhibit the TGF- beta - 1 inducing fibroblast collagen formation. Inhibition ofPDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. Inhamster model, pirfenidone, taken by mouth, that can the preventionand treatment of pulmonary fibrosis induced by bleomycin.Pirfenidone can prevent the sclerosing peritonitis in rats inducedby chemical, can also be keloid grafting for the treatment of nudemice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dosedependent manner serum stimulate uterine fibroids and leiomyomacell DNA synthesis, the compound has no cytotoxic effect, has noeffect on collagen mRNA level also. Pirfenidone in hamsterpulmonary fibrosis model can reduce the disease before the collagenI mRNA level enhancement, reduce the level of the lunghydroxyproline and malondialadehyde and lung preserved ammonia acylhydroxylase activity.

 Packing: 1kg/foil bag; net weight 25kg/drum or according to required

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